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Doctor, what do you think about

Must KnowApplied Basic SciencesthinKbox SBA

Clinical image

Hypertrophic tibial nonunion

Hypertrophic tibial nonunion. Source: Wikimedia Commons — Lindsaydavidson; CC BY 3.0. Image binary is embedded locally in this package; original source and licence are retained.

  • this X-ray?

Non union

Describe what you see

  • I see the lateral view of a right femur with an ante-grade IM nail used to fix a diaphysial fracture. What concerns me is the atrophic non union.
  • Ask for other views

Definition

  • Biological process of fracture healing has come to a stand still which is evident clinically and radiologically.
  • Causes of non union are multiple and my management will be based on the causes which I divide in to
  • Infection
  • Local cause
  • Systemic cause
  • Mechanical

Local causes-infection

  • Any non union is infected unless proved otherwise
  • I would assume that there are no sinuses, wounds healed by secondary intention, history or chronology of events suggestive of infection. How ever I would exclude infection by blood markers and culture of tissue samples next to bone.Mri, leukocyte scan are useful adjutants .
  • mri is most sensitive, but less specific. leukocyte scan is good for acute infection, but in c/c rumbling infection they are less useful.
  • Cierny and mader classification

Key points

Local factors

  • Index injury
    • Fracture personality gustilo etal
    • open fracture
    • compartment syndrome blair
    • soft tissue injury Tscherne
  • Surgical technique
    • Tissue handling
    • tourniquet
    • wound coverage
    • approach
    • distraction
    • reamers
    • appropriate application of fixator/cast

Systemic

  • Patient co morbidities
    • DM
    • COPD
    • PVD
    • Steroids
    • Endocrinopathies
    • VD and V K
  • Patient social
    • Alcohol
    • smoking
    • non compliance

Mechanics

  • Principle applied
  • was it appropriate? achieved?
  • Stability

Management

  • This is a difficult problem
  • Assess the causes and address the causes
  • MDT approach
  • Confer with colleagues with more experience
  • How ever my goals are
    • To achieve union
    • eradicate any infection
    • address shortening/malalignment
    • Achieve good function

Management Planning

  • Host type
  • soft tissue status and coordination with plastic surgeon
  • Bone factors-shortening/alignment/bone loss/joint stiffness

Septic non union

  • 3 stage procedure
  • First stage- remove implant, resect devitalised bone and soft tissue, local/systemic antibiotics, temporising ex fix. Serial blood markers, blood culture, repeated debridement if needed, VAC
  • Second stage- Soft tissue coverage by plastic
  • Third stage- Definitive procedure, nail/plate/circular frame

Hypertrophic no previous surgery

  • If in good alignment and no shortening/gap
  • Functional cast/ LIPUS (Low intensity pulsed Usg)
  • Nail/plate fixation

Atropic no previous Sx

  • Associated gap, shortening and malalignment
  • Circular frame

Aseptic with previous Sx

  • Single stage revision fixation with graft/ BMP after actively ruling out infection

Written/reviewed by Kishore Puthezhath

Professor of Orthopaedics and Consultant Paediatric Orthopaedic Surgeon

FRCS (Tr & Orth) revision resource

Reviewed: September 2026